Interstitial thickening along lymph channels 2 The following features may be seen with lymphoid interstitial pneumonia on HRCT, but the findings are not exclusive to its diagnosis:įeatures tend to be diffuse with mid to lower lobe predominance Lower-zone predominant bilateral reticular opacification Radiographic features Plain radiographįeatures can be non-specific, but may include: In about 80% of patients polyclonal or IgM monoclonal gammopathy is found 8. It is considered a benign lymphoproliferative disorder characterized histologically by diffuse interstitial and alveolar infiltration with polyclonal lymphocytes and plasma cells. If the disease progresses to end-stage respiratory failure, cyanosis and clubbing may develop. Hypertrophy of the salivary glands may be seen in 20% of patients 11. Less frequently, patients may have systemic symptoms such as fever, night sweats, arthralgia, and weight loss. The main clinical symptoms are a gradual onset of dyspnea and cough with approximately 6 months duration. AssociationsĬonsidered the most common lung pathology in these patients 14.Ĭan occur in up to 25% of those with lymphoid interstitial pneumonia 6ĪIDS: particularly if it occurs in the young 9 There is a recognized female predilection (by ~2 fold) most likely attributable to the fact that lymphoid interstitial pneumonia occurs in patients with autoimmune diseases such as Sjögren syndrome, which is by far more common in women 8. However, most of the patients are adults with a mean age of 52-56 years. If a child presents with lymphoid interstitial pneumonia, this can be indicative of AIDS. Lymphoid interstitial pneumonia can occur at any age.
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